The effects of specific drugs on driving skills differ depending on how they act in the brain. For example, marijuana can slow reaction time, impair judgment of time and distance, and decrease coordination. Drivers who have used cocaine or methamphetamine can be aggressive and reckless when driving. Certain kinds of prescription medicines—including benzodiazepines and opioids—can cause drowsiness, dizziness, and impair cognitive functioning (thinking and judgment). All of these effects can increase the chances of vehicle accidents.

Research studies have shown negative effects of marijuana on drivers, including an increase in lane weaving, poor reaction time, and altered attention to the road. Use of alcohol with marijuana makes drivers more impaired, causing even more lane weaving. Some studies report that opioids can cause drowsiness and impair thinking and judgment. Other studies have found that being under the influence opioids while driving can double your risk of having a crash.

For these reasons, many states have laws making it a criminal offense to operate a vehicle under the influence of or while impaired or intoxicated by legal or illegal prescription or recreational drugs, for example—known as drugged driving or driving under the influence of drugs (DUID). And a driver’s use of a prescription medication is not a defense to operating a vehicle while impaired or intoxicated by the medication.

In many states the DUI/DWI statutes are broad enough to prosecute a driver who is under the influence of or impaired or intoxicated by prescription or recreational drugs—as well as alcohol or any other substance, including an inhalant with a vapor-releasing substance. And at least 15 states have per se (pronounced purr-say) drugged driving laws that make it a criminal offense to drive with any detectable amount of certain drugs in your system, or with a minimum prohibited amount of certain drugs, as provided in the state’s statutes. These states include Arizona, Delaware, Georgia, Illinois, Indiana, Iowa, Michigan, Minnesota, Nevada, Ohio, Pennsylvania, Rhode Island, Utah, Virginia, and Wisconsin.

Drugged driving laws are generally located in a state’s statutes—often in the penal code or criminal code.

In Oklahoma, it is illegal to operate a vehicle under the influence of drugs, including both illegal substances and legal medications that impair driving abilities. This falls under the state's DUI (Driving Under the Influence) laws. The effects of drugs on driving skills vary, with marijuana affecting reaction time, judgment, and coordination, while cocaine or methamphetamine use can lead to aggressive and reckless driving. Prescription medications such as benzodiazepines and opioids can cause drowsiness and impair cognitive functions. Oklahoma law does not consider the use of prescription medication as a valid defense for impaired driving. The state's DUI statutes are comprehensive and allow for prosecution of drivers impaired by any substance, not just alcohol. While Oklahoma does not have a per se drugged driving law that makes it a criminal offense to drive with any detectable amount of certain drugs in one's system, driving under the influence of drugs that impair driving ability is still a criminal offense and can lead to serious legal consequences.